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Drug Class and Mechanism: Amlodipine belongs to a class of medications called calcium channel blockers. These medications block the transport of calcium into the smooth muscle cells lining the coronary arteries and other arteries of the body. Since calcium is important in muscle contraction, blocking calcium transport relaxes artery muscles and dilates coronary arteries and other arteries of the body. By relaxing coronary arteries, amlodipine is useful in preventing chest pain (angina) resulting from coronary artery spasm. Relaxing the muscles lining the arteries of the rest of the body lowers the blood pressure, which reduces the burden on the heart as it pumps blood to the body. Reducing heart burden lessens the heart muscle's demand for oxygen, and further helps to prevent angina in patients with coronary artery disease.

Missed Dose: Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

Warnings Precautions: Before taking Norvasc, tell your doctor if you have liver disease; or another disease of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, heart failure, low blood pressure, or coronary artery disease. You may not be able to take Norvasc, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Norvasc is in the FDA pregnancy category C. This means that it is not known whether Norvasc will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Norvasc passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Possible Side Effects: If you experience any of the following serious side effects, stop taking Norvasc and contact your doctor immediately or seek emergency medical treatment:

Other, less serious side effects may be more likely to occur. Continue to take Norvasc and talk to your doctor if you experienceSide effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Aspirin has a downside, however. Because it acts on the overall system that affects bleeding, aspirin also increases the risk of gastrointestinal bleeding, either from an ulcer or gastritis, and the risk of a rare but dangerous form of stroke caused not by a blood clot, but by bleeding in the brain. This fact, and the lack of strong enough evidence to support a change in labeling, led the U.S. Food and Drug Administration panel in December 2003 to vote against including "primary prevention of heart attack" in the indications for use of aspirin on the medication's label... Order generic Norvasc

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The Institute of Medicine recommends people aged 51 to 70 should have 400 IU of vitamin D daily. People over 70 should have 600 IU.

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