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How Taken: Actos is prescribed once daily in doses ranging from 15 to 45 mg. It may be taken any time of the day, with or without meals.
Missed Dose: If a dose is missed on one day, two doses should not be taken the next day to make up for the missed dose.
Possible Side Effects: The most common side effects seen in clinical trials with Actos were
- upper respiratory tract infection, headache, sinusitis, muscle aches, tooth disorders, hypoglycemia, and sore throat.
To date, no formal studies to evaluate drug interactions of actos with other drugs have been conducted. Nevertheless, because it interacts with the liver enzymes that eliminate some other drugs, there is the potential for actos to increase the elimination of such drugs as erythromycin, calcium channel blockers (e.g., Cardizem), cisapride (Propulsid), corticosteroids, cyclosporine, tacrolimus, triazolam (e.g., Halcion), trimetrexate, and HMG-CoA reductase inhibitors (e.g., Lipitor).
Since another thiazolidinedione antidiabetic drug has been associated with liver injury, it is recommended that periodic monitoring of liver-related side effects and liver function be done in patients taking actos.
Side effects while taking Actos which may be due to liver injury include nausea, vomiting, abdominal pain, fatigue, anorexia (loss of appetite), or dark urine. Blood liver tests also are recommended during actos therapy.
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