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Drug Class and Mechanism: Tretinoin is a derivative of vitamin A. Topical Tretinoin is used in the treatment of mild to moderate acne and on skin that has been damaged by excessive exposure to the sun. Tretinoin irritates the skin and causes the cells of the skin to grow (divide) and die more rapidly, that is, it increases the turnover of cells. The number of layers of cells in the skin actually is reduced. In patients with acne, new cells replace the cells of existing pimples, and the rapid turnover of cells prevents new pimples from forming. By a similar mechanism, Tretinoin can reduce some wrinkles, areas of darkened skin, and rough areas of skin, all of which occur in sun-damaged skin. In patients with sun-damaged skin, improvements in the skin usually are seen within the first 3 to 4 weeks of treatment. Brown spots begin to fade after six to eight weeks. Wrinkles decrease or disappear after three to six months. Following application to the skin, a minimal amount of drug is absorbed into the body. The FDA approved topical Tretinoin in 1971.

More Information:

• Serious side effects are not likely to occur. Stop using tretinoin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).
• You may experience some burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, or irritation while you are using tretinoin topical. If these side effects are excessive, talk to your doctor. You may need a lower dose or less frequent applications of tretinoin topical.
• If you notice a change in your skin color, contact your doctor.
• Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage: Store at room temperature away from sunlight. Keep this and all medications out of the reach of children.

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