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Missed Dose: If you miss a dose of Indocin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Warnings Precautions: Do not use Indocin if:

• you are allergic to any ingredient in Indocin;
• you have had a severe allergic reaction (e.g., severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (e.g., ibuprofen, celecoxib);
• you have recently had or will be having bypass heart surgery;
• you are taking diflunisal, another NSAID (e.g., ibuprofen), or triamterene;
• you are in the last 3 months of pregnancy;

• Indocin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Indocin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Indocin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Indocin with food will not reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Indocin is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (e.g., ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Indocin unless your doctor tells you to.
• Indocin may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take Indocin.
• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Indocin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Indocin with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
• Indocin should be used with extreme caution in children younger than 14 years old; safety and effectiveness in these children have not been confirmed.
• Indocin may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Indocin while you are pregnant. Indocin is found in breast milk. Do not breast-feed while taking Indocin.

Possible Side Effects: Check with your doctor if any of these most common side effects persist or become bothersome:

• constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach upset.

• severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

Storage: Store Indocin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Indocin out of the reach of children and away from pets.

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